It seemed more fact-based when it was done in interrogation - the unsub was already scared of it, Hotch was just saying "You know this will happen - we can prevent it if you work with us." - he was offering an out. Prentiss was saying "This is going to happen and you can't stop it, and I'm glad." Which is totally different, moral wise. (My personal feelings aside, law enforcement people should be better than that, they really should.)